Shark cartilage extract appears to block the two main pathways that contribute to the process of angiogenesis, matrix metalloproteases and the vascular endothelial growth factor signalling pathway (Anon 2004). The effect is due to several different constituents that have been isolated from shark cartilage and identified as exerting _

anti-angiogenic activity (Dupont et al 1998, Gonzalez et al 2001, Shen et al 2001, Shark cartllage ioy4

Sheu et al 1998) in various experimental models. > 2007 Elsevier Australia

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