Altered Cellular Signalling

Flavonoids have been shown to modulate tumour pathology in vitro and in animal models, and the pentameric procyanidin fraction isolated from cocoa is reported to slow the growth of cultured human aortic endothelial cells (Kenny et al 2004a), as well as inhibit the proliferation of human dermal microvascular endothelial cells in vitro through inhibition of tyrosine kinase ErbB2 expression. This has led to the suggestion polyphenols may influence endothelial growth signaling in vitro, with potential beneficial effects for specific neoplasias in which cells over-express ErbB2 (Kenny et al 2004b).

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