Aids And

Low vitamin B12 levels are often observed in patients infected with HIV type 1 (HIV-1) (Remacha & Cadafalch 1999, Remacha et al 1993). One study identified deficiency in 10-35% of all patients seropositive for HIV, presumably as a result of decreased intake, intestinal malabsorption and/or abnormalities in plasma binding proteins or antagonism by the drug azidothymidine. Importantly, as serum cobalamin levels declined, progression to AIDS increased and neurological symptoms worsened.

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