Ageing

In a randomised, double-blind, placebo-controlled trial of 84 elderly subjects (aged 70-92 years) who experienced onset of fatigue after slight physical activity, l-carnitine (2 g twice daily) for 30 days resulted in significant improvements in total fat mass, total muscle mass, lipid profiles, as well as overall improvements in physical and mental fatigue (Pistone et al 2003). Animal studies have demonstrated that supplementation of carnitine (300 mg/kg/day) and lipoic acid (100 mg/kg/day) for 30 days protects mitochondria from ageing by raising mitochondrial energy production and reversing the age-associated decline in mitochondrial enzyme activity (Savitha et al 2005). Studies using standard oral doses of l-carnitine in humans are required to confirm these effects.

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