Adverse Reactions

There have been several case reports of Sho-saiko-to-induced interstitial pneumonia (Liu et al 2002). One case of Sho-saiko-to-induced pneumonia in a patient with autoimmune hepatitis was reported (Katou etal 1999); however, direct toxicity is very low.

Toxicity studies of three different traditional Chinese/Japanese formulations containing baical suggests a very low acute or subchronic toxicity for the herbs in them. The studies found no herb-related abnormalities such as changes in body weight or food consumption, abnormalities on ophthalmological and haematological examination, urinalysis and gross pathological examination, changes in organ weights or optical microscopic examination (lijima et al 1995, Kanitani et al 1995, Kobayashi etal 1995, Minematsu etal 1992, 1995). The acute lethal activity of wogonin is low, with an LD50 of 3.9 g/kg (Kwok et al 2002).

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