Adverse Reactions

Studies using doses of 1 50 mg/day have found it to be well tolerated. SIGNIFICANT INTERACTIONS

Controlled studies are not available, therefore interactions are theoretical and based on evidence of pharmacological activity. ANTIPLATELET DRUGS

Additive effect theoretically possible— observe patient. ANTICOAGULANT DRUGS

Increased risk of bleeding theoretically possible— caution. IRON AND IRON-CONTAINING PREPARATIONS

Decreased iron absorption. Tannins can bind to iron, forming insoluble complexes — separate doses by 2 hours.

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