Adverse Reactions

Theoretically, gastric irritation can occur, because of the saponin content. There are two case reports of hepatotoxicity resulting from the consumption of a weight-loss formula containing gymnema and other herbs, including Garcinia cambogia, willow bark, glucomannan, green tea and guarana (Stevens et al 2005). In one study, gymnema was found to have a toxic effect in mice, producing increased lipid peroxidation at doses of 26.8 mg/kg, but was safe and antiperoxidative at doses of 13.4 mg/kg (Gholap & Kar 2005). In another study it was concluded that there was no toxic effect in rats treated with gymnema at doses of more than 500 mg/kg for 52 weeks (Ogawa et al 2004).

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