Adverse Reactions

Tolerability in 98% of the clinical studies is good or very good (Bilia 2002). In a few cases (less than 0.001 %), gastrointestinal upset, headaches and dizziness were reported. It does not appear to alter heart rate and blood pressure, change cholesterol and triglyceride levels or increase intraocular pressure in clinical studies (Chung etal 1999).

Rare case reports of subarachnoid haemorrhage, subdural haematoma, intracerebral haemorrhage, subphrenic haematoma, vitreous haemorrhage and postoperative bleeding have been documented.

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