Adverse Reactions

High doses of supplements may induce the following:

• arterial calcification

• arrhythmia

• gastrointestinal distress including nausea, vomiting and constipation

• hypercalcaemia

• nephrotoxicity, manifesting as polyuria, polydipsia and nocturia. SIGNIFICANT INTERACTIONS

Only those interactions relevant to the oral supplemental forms of vitamin D will be reviewed.

A number of pharmacokinetic and pharmacodynamic interactions are possible with vitamin D and a range of medicines and minerals.

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