Adverse Reactions

Large doses can cause gastrointestinal upset, diarrhoea and vomiting (Tierra 2005).

Central nervous system and respiratory depression (Malhotra et al 1965b), decreased body temperature (Malhotra et al 1965b), gastrointestinal upset (Lindner 1996) and kidney and liver abnormalities (Arseculeratne et al 1985) have been noted.

Acute toxicity studies in animals show a good margin of safety with a high therapeutic index (Aphale et al 1998, Rege et al 1999, Sharada et al 1993, Singh et al 2001, 2003).

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