According To Clinical Studies

• Preconception care or early pregnancy supplementation: 400-600 ¡jg /day.

• Preconception and pregnancy supplementation in women with a previous NTD birth: 4 mg/day.

• Anticonvulsant-induced deficiency: 1 5 mg/day (under supervision).

• Prevention of cervical cancer: 800-10 000^g/day.

• Prevention of colorectal cancer in ulcerative colitis patients: 1-5 mg/day.

• Alzheimer's dementia and cognitive changes in the elderly: doses adequate to correct deficiency if present.

• Depression: 50 mg methylfolate daily.

• Acute psychiatric presentation: 1 5-30 mg methylfolate daily in combination with standard psychotropic treatment.

• Hyperhomocysteinaemia: 500-5000^g/day.

• Methotrexate toxicity: 5 mg/week.

• OCP-induced folate deficiency: 2 mg/day.

• Periodontal disease: rinse mouth with a solution of folate (5 mg/dose) twice daily.

• Prevention of restenosis after percutaneous coronary intervention: 1 mg in combination with vitamin B12 (400/jg) and vitamin B6 (10 mg) daily.

• Ulcerative colitis: 15 mg/day.

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