Radiation Induced Hepatitis

Due to its size and anatomical location in the abdomen, the liver is frequently affected secondarily by radiation therapy of extrahepatic malignancies. Within six months of radiation injury, diffuse edema of the liver can be seen, appearing as increased SI on T2-weighted images and decreased SI on T1-weighted images [68].

Portal flow is generally reduced in patients with radiation injured regions of the liver, and, as in the case of patients with concomitant fatty infiltration, the deposition of fat in these areas is usually reduced [22].

Fig. 4a-h. Primary sclerosing cholangitis. T2-weighted images (a-d) show diffusely distributed regions of biliary dilatation (arrows) as well as segmental atrophy (arrowhead in b) of segments II and III of the liver. Due to the already advanced stage of the disease, hypertrophy of segment I (c) can be detected. Unenhanced T1-weighted images (e) reveal decreased SI of the liver parenchyma. Irregular enhancement due to inflammatory changes can be seen on Tl-weighted dynamic imaging in the arterial phase (f) and portal-venous phase (g). In the hepatobiliary phase after injection of 0.05 mmol/kg BW Gd-BOPTA (h), a patchy pattern can be detected that corresponds to the affected areas of liver parenchyma where uneven uptake and excretion of Gd-BOPTA has occured

Fig. 4a-h. Primary sclerosing cholangitis. T2-weighted images (a-d) show diffusely distributed regions of biliary dilatation (arrows) as well as segmental atrophy (arrowhead in b) of segments II and III of the liver. Due to the already advanced stage of the disease, hypertrophy of segment I (c) can be detected. Unenhanced T1-weighted images (e) reveal decreased SI of the liver parenchyma. Irregular enhancement due to inflammatory changes can be seen on Tl-weighted dynamic imaging in the arterial phase (f) and portal-venous phase (g). In the hepatobiliary phase after injection of 0.05 mmol/kg BW Gd-BOPTA (h), a patchy pattern can be detected that corresponds to the affected areas of liver parenchyma where uneven uptake and excretion of Gd-BOPTA has occured

Fig. 5a-g. Primary sclerosing cholangitis and development of CCC. The T2-weighted HASTE image (a) reveals inflammation in the area of the left main intrahepatic bile duct (arrows) and some minor dilatations of intrahepatic ducts (arrowheads). At one year follow-up, an analogous T2-weighted HASTE study (b) reveals development of a tumor in the area of the biliary bifurcation (arrow). On the corresponding Tl-weighted image (c) the tumor is markedly hypointense and shows diffuse infiltration along the biliary tracts. The arterial phase image (d) acquired during the dynamic series after injection of 0.05 mmol/kg BW Gd-BOpTA reveals that the tumor is hypovascular. On the subsequent portal-venous phase image (e), indistinct margins are apparent. In the equilibrium phase (f), the tumor shows delayed homogeneous uptake of Gd-BOPTA and only some central parts remain hypointense compared to normal liver tissue. This behavior is typical of CCC. In the hepatobiliary phase (g), the tumor is again hypointense and indistinct margins and infiltration along the bile ducts are again visible

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment