Systemic accumulation of iron may be caused by hemolysis in which hemoglobin is liberated from red blood cells. While extravascular (e.g. splenic) hemolysis leads to a reticuloendothelial deposition of iron, intravascular hemolysis causes hepatocel-lular accumulation, since the released hemoglobin binds to plasma haptoglobin, which is taken up by hepatocytes. If the serum hemoglobin level exceeds the transport capacity of haptoglobin, it is filtered through renal glomeruli, reabsorbed and stored within proximal convoluted tubule epithelial cells. For this reason, intravascular hemolysis is characterized by an accumulation of iron in the liver and renal cortex, but not in the spleen. Dis eases which lead to intravascular hemolysis and thus show this characteristic imaging pattern include paroxysmal nocturnal hemoglobinuria and sickle cell disease [6l].
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One of the main home remedies that you need to follow to prevent gallstones is a healthy lifestyle. You need to maintain a healthy body weight to prevent gallstones. The following are the best home remedies that will help you to treat and prevent gallstones.