FLC is a slow-growing neoplasm of unknown etiology with different clinical and pathological features of HCC and HB. It is frequently detected in patients of adolescent age and has no predilection for either gender . It generally occurs in the non-cirrhotic liver with normal AFP levels. There are no known risk factors and the prognosis is better than for HCC due to the better chances of surgical resection.
The most common symptoms are the same as those encountered in adult patients: abdominal pain, hepatomegaly, anorexia, weight loss, and less frequently, pain, fever and jaundice. In two out of three cases a mass is appreciable in the right hypochondrium.
As with HCC, the imaging features of FLC on US, CT and MR imaging in pediatric subjects are largely indistinguishable from those in adult subjects (see Chapt. 6, "Imaging of Malignant Focal Liver Lesions", section 6.1.2,"Fibrolamellar Hepa-tocellular Carcinoma").
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