Salmonella Pathogenicity Island

Genes encoded by Salmonella pathogenicity island 2 (SPI2) have been shown to be iron-responsive with transcription upregulated during iron chelation (Zaharik et al. 2002). The S. Typhimurium SPI2-associated genes are required for intramacrophage survival and systemic infection, which are iron-deplete environments. Microarray analysis indicates that the transcription of 13 SPI2-associated genes (Fig. 13.2,

CM TO O

Energy metabolism

□ Transport and binding proteins

□ Cellular processes

□ Amino acid biosynthesis

□ Central intermediary metabolism

□ Cell envelope

□ Biosynthesis of cofactors

□ Miscellaneous

Fig. 13.1 Increased S. Typhimurium gene expression in the presence of 2 mM Norepinephrine

□ Energy metabolism

□ Transport and binding proteins

□ Cellular processes

□ Amino acid biosynthesis

□ Central intermediary metabolism

□ Cell envelope

□ Biosynthesis of cofactors

□ Miscellaneous

Fig. 13.1 Increased S. Typhimurium gene expression in the presence of 2 mM Norepinephrine

□ Transport and binding proteins

□ Biosynthesis of cofactors

□ Purines and pyrimidines

□ Cell envelope

□ Energy metabolism

□ Cellular processes

□ Regulatory functions

□ Miscellaneous

Fig. 13.2 Decreased S. Typhimurium gene expression in the presence of 2 mM Norepinephrine

□ Transport and binding proteins

□ Biosynthesis of cofactors

□ Purines and pyrimidines

□ Cell envelope

□ Energy metabolism

□ Cellular processes

□ Regulatory functions

□ Miscellaneous

Fig. 13.2 Decreased S. Typhimurium gene expression in the presence of 2 mM Norepinephrine

Protein fate; Bearson and Bearson, unpublished results) is repressed in the presence of 2 mM NE in Serum-SAPI medium compared to the absence of NE, providing additional evidence that Serum-SAPI medium is iron-deplete (Bearson et al. 2008).

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