Class 1. Salicylates; tannins (AHP, 1997). Commission E reports for oral use of bark, contraindications, adverse effects, and interactions: on theoretical grounds similar to those of the salicylates (AEH). (All plants contain salicylates.) In view of the lack of toxicological data, excessive use, especially during lactation and pregnancy, should be avoided. Individuals with aspirin hypersen-sitivity, asthma, diabetes, gastrosis, gout, hemophilia, hepatosis, hypothrombinaemia, nephrosis, and peptic ulcers should be cautious with salicylates. Alcohol, barbiturates, and oral sedatives may potentiate salicylate toxicity. Beware of salicylate interaction with oral anticoagulants, methotrex-ate, metoclopramide, phenytoin, pronebecid, spironolactone, and valproate. Salicylates excreted in breast milk reportedly can cause macular rashes in breast-fed babies. Salicylate toxicity may cause dermatosis, gastrosis, hematochezia, nausea, nephrosis, tinnitus, and vomiting (CAN). Excessive use of the tannin-rich bark may cause diarrhea and nausea (SKY). Still, "willow is much safer than aspirin" (SKY). Not for use during viral infections because of [remote theoretical; JAD] possibility of Reye's syndrome (WAM).
Was this article helpful?