Betablocker and diuretic combinations

Several beta-blocker and diuretic combinations were marketed a number of decades ago when beta-blockers became available in the USA (Figure 12). In most of these fixed combinations, the beta-blocker is combined with 25 mg, or even 50 mg, of HCTZ (or the corresponding dose of a thiazide derivative), a dose that, by today's standard, would have to be considered high. It has been learned that HCTZ doses of 12.5 mg, and even 6.25 mg, lower BP and cause fewer endocrine metabolic adverse effects than...

Isolated systolic hypertension

There are three main reasons why isolated systolic hypertension has become increasingly important over the past few years We are seeing more and more elderly patients, and isolated systolic hypertension is the most common form of high BP in the geriatric population. Systolic BP has finally been recognized as the most powerful predictor of cardiovascular morbidity and mortality and, therefore, treatment of systolic BP has become more important than that of diastolic BP. The treatment goals of...