Vitamin K

Many proteins are dependent on vitamin K for the carboxylation of 7-carboxyglutamyl (Gla) residues. Several of these vitamin K-dependent proteins play integral roles in the bone matrix. Osteocalcin, one of the vitamin K-dependent proteins, is the most abundant noncollagenous protein in bone. Osteocalcin contains three Gla residues that require vitamin K for carboxylation. The ability of osteocalcin to bind to the hydroxyapatite fraction of bone is dependent on its degree of carboxylation. Deficiency of vitamin K increases the fraction of undercarboxy-lated osteocalcin in the circulation. In addition to osteocalcin, other vitamin K-dependent proteins (including matrix Gla protein and protein S) are found in bone and cartilage. Research is needed to elucidate the impact of vitamin K deficiency on risk of osteoporosis and fracture. Because of the known relationship between vitamin K and several crucial bone proteins, optimal status of this vitamin should be achieved to promote skeletal health.

Was this article helpful?

0 0
Diet And Exercise Expertise

Diet And Exercise Expertise

Get All The Support And Guidance You Need To Be A Success At Dieting And Exercise. This Book Is One Of The Most Valuable Resources In The World When It Comes To Better Physical Personal Development Through Better Living.

Get My Free Ebook


Post a comment