Vitamin E

The ATBC trial showed no significant effect of a-toco-pherol supplementation (50mg/day) on risk of lung, pancreatic, colorectal, or urinary tract cancers among heavy smokers (Table 3). However, in a post hoc subgroup analysis a 34% reduction in the risk of prostate cancer was seen in men who received this supplement. Although interesting, prostate cancer was not a primary endpoint of this study, and no other studies have supported a preventative effect of vitamin E for prostate cancer. The Heart Protection Study found no effect of vitamin E in combination with vitamin C and /3-carotene on cancer incidence or mortality. Two smaller, short-term intervention studies found no effect of a-tocopherol supplementation on mammary dysplasia or benign breast disease. Several trials have also been unable to demonstrate a protective effect of vitamin E supplementation on the risk or recurrence of colorectal adenomatous polyps.

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