Periodic distribution of high-dose vitamin A supplements, either universally to all preschool children or to targeted high-risk groups, has been the most widely practiced intervention for the prevention and treatment of vitamin A deficiency throughout the world. Giving a high dose of vitamin A every
4-6 months is based on the assumption that vitamin A is stored in the liver and mobilized, as needed, to meet the demands of target tissues. This is in contrast to iron supplements, which need to be given on a daily or weekly basis.
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