Very Low Density Lipoprotein Synthesis

The endogenous pathway for cholesterol transport focuses on the liver with the synthesis and secretion of VLDL particles. Cholesterol in these triacylgly-cerol-rich particles comes from multiple sources: endogenous synthesis, diet, and plasma lipoproteins. Catabolism of VLDL by LPL leads to formation of intermediate-density lipoproteins (IDLs), which can either be taken up by the liver or undergo further metabolism to form LDL. Low-density lipoproteins contain apo-B100 and account for 60-80% of the plasma cholesterol in most individuals. During lipo-lysis of VLDL triacylglycerol, the lipoproteins containing apo-B become enriched with cholesteryl ester through the plasma CETP-catalyzed net transfer of cholesteryl ester from HDL. This process, called reverse cholesterol transport, moves cholesterol from extrahepatic tissues to HDL to VLDL-IDL-LDL and eventual uptake by the liver.

Approximately 70% of the LDL degraded each day is degraded by the hepatic LDL receptor pathway.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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