If the deficiency is nutritional it is usually treated in the first instance with dietary supplements. In the past, daily supplements of 5.0mgday_1 have been used but more recent evidence suggests that such high levels would only be appropriate for the immediate treatment of an overt deficiency. More long-term treatment would recommend dietary changes to improve folate intake. In practice, to achieve effective changes is very difficult so the recommendation might be to improve intake through foods fortified with the synthetic form of the vitamin, namely folic acid, or the use of supplements of folic acid. In both of these instances the aim is to achieve a maximum increased intake via folic acid of 400 mgday-1. Long-term ingestion of larger amounts are not recommended because of their ability to mask the diagnosis of vitamin B12 deficiencies (discussed above). Other causes of folate deficiency are treated by removing the cause, e.g., alcohol abuse.
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