Tissues

Biotin concentrations in plasma are small relative those of other water-soluble vitamins. Most biotin in plasma is free, dissolved in the aqueous phase of plasma. However, small amounts are reversibly bound and covalently bound to plasma protein (approximately 7 and 12%, respectively); binding to human serum albumin likely accounts for the reversible binding. Biotinidase has been proposed as a biotin binding protein or biotin carrier protein for the transport into cells. A biotin binding plasma glycoprotein has been observed in pregnant rats. Although the importance of protein binding in the transport of biotin from the intestine to the peripheral tissues is not clear, the immunoneutralization of this protein led to decreased transport of biotin to the fetus and early death of the embryo.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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