Tissue Uptake and Storage

The body pool of cholesterol is approximately 145 g, with one-third of this mass localized in the central nervous system. The remainder of the metabolically active cholesterol pool exists in the plasma compartment (7.5-9 g) and as constituents of body tissues. In humans, tissue cholesterol levels are relatively low, averaging 2 or 3 mg/g wet weight. Little information exists regarding changes in hepatic and extrahepatic tissue cholesterol concentrations with changes in dietary cholesterol intake. Animal studies, which are usually carried out using very high levels of dietary cholesterol, have shown that hepatic cholesterol can increase from 2-fold up to 10-fold, depending on the species and other dietary constituents, when dietary cholesterol is increased.

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