Supplementation

Based upon their excitatory effects on the central nervous system both glycine and d-serine have been implicated in the treatment of schizophrenia. As adjuvant therapy to standard psychopharmacological treatment they may reduce the negative symptoms of the disease.

High doses of threonine in adults have been used as tentative therapy for spastic syndromes, a therapy that probably acts through increased glycine formation. A negative effect of excessive threonine, which is abundant in bovine infant formula nutrition, has been considered in experimental studies on brain development, and it has been suggested that this happens through its conversion to glycine and serine, or through competition of amino acid transport across the blood-brain barrier.

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