Secretin

Secretin is produced by cells in the duodenal mucosa in response to the appearance of acidity and chyme. It performs at least four major functions associated with the passage of the meal through the duodenum. It stimulates the pancreatic duct and acinar cells to produce copious aqueous NaHCO3 solution, it

Table 3 Functions of the major gastrointestinal hormones

Hormone Stimulus Function

Table 3 Functions of the major gastrointestinal hormones

Hormone Stimulus Function

Gastrin

Protein in the stomach

Stimulates gastric secretion

Promotes gastric motility

Promotes ileal motility

Promotes colonic motility

Relaxes ileocaecal valve

Trophic action on gastric and intesintal mucosae

Secretin

Acid in the duodenum

Inhibits gastric secretion

Inhibits gastric motility

Stimulates pancreatic juice flow

Stimulates bile flow (HCO3)

Trophic action on pancreatic exocrine tissue

Cholecystokinin

Fat/protein in duodenum

Inhibits gastric secretion

Inhibits gastric motility and gastric emptying

Stimulates pancreatic enzymes

Gall bladder contraction

Sphincter of Oddi relaxation

Trophic action on pancreatic exocrine tissue

Satiety signals

GIP

Duodenal chyme

Inhibits gastric emptying Inhibits gastric secretion

Stimulates insulin secretion from pancreatic islets

GIP, glucose-dependent insulinotrophic peptide.

GIP, glucose-dependent insulinotrophic peptide.

promotes a bicarbonate-rich bile flow, it inhibits gastric emptying, and it inhibits gastric secretion. The secretin secretion rate decreases as acidity production from the stomach decreases.

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