Pathological Losses

Conditions that cause excessive bleeding additionally compromise iron status. Approximately 1 mg of iron is lost in each 1 ml of packed red blood cells. Excessive losses of blood may occur from the gastrointestinal tract, urinary tract, and lung in a variety of clinical pathologies, including ulcers, malignancies, inflammatory bowel disease, hemorrhoids, hemoglobinuria, and idiopathic pulmonary hemosi-derosis. In developing countries, parasitic infestation with hookworm and schistosomiasis can contribute substantially to gastrointestinal blood loss and iron deficiency.

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