Oxidation and cancer

Although PUFA are the most reactive of substrates for ROS attack leading to lipid peroxidation, interest is centering on the detection of oxidized nucleic acids as an indicator of pro-oxidant conditions. It

Initiation Promotion Malignant conversion

Figure 4 The role of oxidants in multistage carcinogenesis. Reproduced with permission from Guyton KZ and Kensler TW (1993) Oxidative mechanisms in carcinogenesis. British Medical Bulletin 49: 523-544.

_ Clinical cancer

Initiation Promotion Malignant conversion

Figure 4 The role of oxidants in multistage carcinogenesis. Reproduced with permission from Guyton KZ and Kensler TW (1993) Oxidative mechanisms in carcinogenesis. British Medical Bulletin 49: 523-544.

has been indicated that significant oxidative damage occurs in vitro and contributes to the etiology of cancer. It has become apparent that many genotoxic agents act through the common mechanism of oxidative damage to DNA. Oxidative processes may be responsible for initiating carcinogenic changes via DNA oxidative damage and may also act as tumor promoters, modulating the expression of genes that regulate cell differentiation and growth and act synergistically with the initiators. Animal studies have indicated diets containing high levels of C18:2 as strong promoters of tumors, and this may be as a result of increased oxidative stress. The fact that MUFA are much less readily oxidized may therefore confer a protective effect against carcinogenesis.

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