It is estimated from the results of the Medical Research Council trial that approximately 30% of
NTDs are not folate-related. The causes of this group of NTDs are unknown but are likely to include genetic and environmental factors. In this context, recent reports on obesity and NTDs are most interesting. Further research on this subject should result in a better understanding of the complex aetiology of NTDs. Nutritional factors other than folate may be involved—for example, vitamins B and C and zinc, as noted previously, and other nutrients.
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