C L Keen, J L Ensunsa, B Lönnerdal and S Zidenberg-Cherr, University of California at Davis, Davis, CA, USA
© 2005 Elsevier Ltd. All rights reserved.
The essentiality of manganese was established in 1931, when it was demonstrated that a deficit of it resulted in poor growth and impaired reproduction in rodents. Manganese deficiency can be a practical problem in the swine and poultry industries, and it may be a problem in some human populations. Conversely, manganese toxicity can be a significant human health concern. Here, literature related to manganese nutrition, metabolism, and metabolic function is reviewed.
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