Local regulation of bone cell proliferation maturation and function by polypeptide growth factors

A variety of growth factors (e.g., fibroblast growth factor and IGF-I) stimulate the division of preosteo-blastic cells. Other signal molecules (e.g., transforming growth factor ft) are associated with developmental events such as the formation of the vertebrae, jaws, and palate. Osteoblasts produce many of these growth factors themselves and deposit them in their extracellular matrix, suggesting that they coordinate small groups of cells at specific locations. Osteoclast recruitment is regulated by a variety of blood cell growth factors, termed 'colony stimulating factors'. Several of these are produced by osteoblastic cells. Osteoblasts have also been shown to produce factors that stimulate mature osteoclasts to resorb.

Was this article helpful?

0 0
Losing Weight Without Starving

Losing Weight Without Starving

Tired of Trying To Loose Weight And It Never Works or You Have To Starve Yourself Well Here's A Weight Loss Plan That takes Care of Your Weight Problem And You Can Still Eat. In This Book, You’ll Learn How To Lose Weight And Not Feel Hungry! In An Easy Step-By-Step Process That Enables You To Feel Good About Loosing Weight As Well As Feeling Good Because Your Stomach Is Still Full.

Get My Free Ebook


Post a comment