Introduction

Celiac disease is the end result of a collision between the human immune system and the widespread cultivation of wheat, where the point of contact is the lining of the small intestine. This collision results in inflammatory and architectural changes of the absorptive mucosa in those susceptible to celiac disease. The inflammation leads to the destruction and eventual loss of the absorptive surface (villi), increased net secretion, and malabsorption, leading to a multitude of consequences. Celiac disease predominantly affects Caucasians, and it is relatively rare in peoples from sub-Saharan Africa and the Far East, which may be due to different genetic backgrounds and/or the absence of wheat from the diet. The disease occurs in people who carry the particular tissue types HLA-DQ2 or HLA-DQ8, which appear to play an essential role in the disease pathogenesis. The inflammation usually resolves completely with the exclusion of gluten from the diet, will recur if gluten is reintroduced, and, as such, is regarded as permanent. While once thought to be a rare disease, it is recognized as a common chronic disorder that affects as many as 1% of some

Western populations. Indeed, in some populations, it is regarded as the most common genetic disease that affects the gastrointestinal tract. It is now frequently detected by the presence of circulating autoantibodies against tissue transglutaminase, which is released in the damaged intestine. The final diagnosis of celiac disease is defined by biopsy evidence of the characteristic inflammatory changes in the small intestine and ultimately a response to the gluten-free diet.

Living Gluten Free

Living Gluten Free

A beginners guide that will reveal how living "G" free can help you lose weight today! This is not a fad diet, or short term weight loss program that sometimes makes you worse off than before you started. This is a necessity for some people and is prescribed to 1 out of every 100 people on earth by doctors and health professionals.

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