Patients who require PN are often predisposed to infectious complications. The catheter hub is often the entry site, with skin flora such as Staphylococcus epidermidis, Staphylococcus aureus, or Candida being the most common organisms, along with gram-negative enteric bacteria possibly from bacterial translocation. Antibiotic treatment through the central line is often successful without replacement of the catheter using antibiotic combinations such as vancomycin and gentamicin or with an antibiotic lock.
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