Infants and Children

The high concentration of circulating folate in newborn infants coincides with the rapid rate of cell division in the first few months of life and is reflected in the higher folate requirement for infants on a weight basis than for adults. Though the recommendation standards (see Table 2) may underestimate the quantities consumed by many breastfed infants, intake is generally sufficiently above the recommendations that folate deficiency is unlikely.

Data on requirements for older children are sparse, so recommendations for up to adolescence are based on interpolations between the values for very young children and those for adults. Daily recommended levels are above 3.6 mgperkg of body weight, an amount associated with no overt folate deficiency in children and shown to maintain plasma folate concentrations at a low but acceptable level.

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