Hydroxyl Containing Amino Acids Serine and Threonine

These are polar, very weakly acidic molecules but uncharged at neutral pH. They can form hydrogen bonds and are thus quite soluble. Threonine has an additional chiral centre, but again only l-threonine is found in proteins. Serine is found at the active centre of some enzymes. It is also the usual site of

Figure 3 Peptide bond formation.

attachment for the carbohydrate residues in glycoproteins and for the phosphoryl groups in phosphoproteins.

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