Histidine is the precursor for histamine, which is important for the immune system by mediating growth and functionality of immune cells. Excessive release of histamine from mast cells induces the clinical signs of allergy (dilation of capillaries and larger blood vessels, increased capillary permeability and swelling, itching, and anaphylactic shock). These phenomena are effected via the Hj receptor, which is found in smooth muscle cells of the vascular wall and bronchi, among others. Furthermore, histamine acts as a neurotransmitter and mediates gastric acid production. The latter occurs via the H2 receptor found in gastric mucosa. There is no literature available on the potential relationship between histidine availability and histamine production and action.
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