Glutathione

Glutathione is a naturally occurring tripeptide that is known to exist in millimolar quantities in cells. The reduced form (GSH) has exposed -SH groups associated with an internal cysteine residue that has been shown to figure prominently in the stability of enzymes that have -SH groups at the active site. Glutathione partakes in many biological reactions such as amino acid transport, heavy metal transport, and antioxidant activity. Its cofactor role, however, should not be overlooked since GSH has been shown to activate many enzymes or retain their catalytic effectiveness during assays. One suspects, with justification, that this could be one of the functions of GSH in vivo.

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