Gluconeogenesis

The brain can normally only metabolize glucose as an energy source. Therefore, it is very important to maintain relatively constant levels of circulating glucose. In normal circumstances, glycogen serves as a source of blood glucose as free fatty acids from adipose tissue and ketone bodies from the liver are used preferentially as metabolic fuels by muscle and some other tissues. However, this still leads to the exhaustion of glycogen reserves within 12-18 h.

glycine methionine tryptophan cysteine alanine

\7 Pyruvate tyrosine -tryptophan leucine* isoleucine lysine*

phenylalanine

Acetyl-CoA

Acetoacetyl-CoA

asparagine —aspartate i Oxaloacetate asparagine phenylalanine aspartate i \> Fumarate tyrosine

Citrate

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