General Guidelines for the Treatment of Lipoprotein Abnormalities for CHD Prevention

There is a clear benefit from lowering LDL cholesterol with diet or drug therapy in patients with hyperlipidemia or CHD or both. Dietary therapy includes using diets that are restricted in total fat (<30% of calories), saturated fat (<7% of calories), and cholesterol (<200 mg day-1). Pharmacological therapies include anion exchange resins, niacin, and HMG CoA reductase inhibitors. The latter agents have been demonstrated to also lower CHD mortality. It should be noted that dramatic interindividual variations have been demonstrated in response to diet and drug therapies. Consequently the efficacy of hypolipidemic therapies will vary from individual to individual. More information is needed about the benefits of HDL cholesterol raising in patients with low HDL cholesterol levels as well as the benefits of lowering triacylglycerol plasma concentrations, and more specifically the triacylgly-cerol carried in lipoprotein remnants. This is also true regarding the benefits of Lp(a) lowering using niacin in patients with elevated Lp(a) levels.

See also: Body Composition. Cholesterol: Sources, Absorption, Function and Metabolism; Factors Determining Blood Levels. Coronary Heart Disease:

Hemostatic Factors; Lipid Theory; Prevention. Fatty Acids: Metabolism; Monounsaturated; Omega-3

Polyunsaturated; Omega-6 Polyunsaturated; Saturated; Trans Fatty Acids. Fertility.

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