Gastrin is secreted from the gastric antral mucosa in response to food in the stomach, particularly a meal high in protein. Gastrin passes into the blood and stimulates a large range of responses along the whole gastrointestinal tract involving both secretion and motility. The general physiology of gastrin is that of a promoter of gut function as food begins to pass along the gut and as a remover of the remnants of the previous meal. Gastrin secretion ceases as acidity rises within the stomach and duodenum.
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