Bergstrom S, Danielsson H, Klenberg D, and Samuelsson B (1964) The enzymatic conversion of essential fatty acids into prosta-glandins. Journal of Biological Chemistry 239: 4006-4009.
Boers M (2001) NSAIDs and selective COX-2 inhibitors: competition between gastroprotection and cardioprotection. Lancet 357: 1222-1223.
Dyerberg J and Bang HO (1979) Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet 2: 433-435.
Drazen JM, Israel E, and O'Bryne PM (1999) Treatment of asthma with drugs modifying the leukotriene pathway. The New England Journal of Medicine 340: 197-206.
Fitzgerald GA and Patrono C (2001) The coxibs, selective inhibitors of cyclooxygenase-2. The New England Journal of Medicine 345: 433-442.
Funk CD (2001) Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 294: 1871-1875.
Harris RC and Breyer MD (2001) Physiological regulation of COX-2 in the kidney. American Journal of Physiology 281: F1-11.
James MJ, Gibson RA, and Cleland LG (2000) Dietary poly-unsaturated fatty acids and inflammatory mediator production. American Journal of Clinical Nutrition 71: 343s-348s.
Hui Y and Funk CD (2002) Cysteinyl leukotriene receptors. Biochemical Pharmacology 64: 1549-1557.
McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, and Fitzgerald GA (1999) Systemic biosynthesis of prosta-cyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2. Proceedings of the National Academy of Science USA: 96: 272-277.
Narumiya S and FitzGerald GA (2001) Genetic and pharmacological analysis of prostanoid receptor function. The Journal of Clinical Investigation 108: 25-30.
Prescott SM (2000) Is cyclooxygenase-2 the alpha and the omega in cancer? The Journal of Clinical Investigation 105: 15111513.
Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, and Serhan CN (1987) Leukotrienes and lipoxins: structures, biosynthesis and biological effects. Science 237: 1171-1176.
Samuelsson B and Funk CD (1989) Enzymes involved in the biosynthesis of leukotriene B4. Journal ofBiological Chemistry 264: 19469-19472.
Serhan CN and Levy B (2003) Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics. Proceedings of the National Academy of Science USA 100: 8609-8611.
Smith WL and Lanenbach R (2001) Why there are two cyclo-oxygenase isozymes. The Journal of Clinical Investigation 107: 1491-1495.
Smith WL, DeWitt DL, and Garavito RM (2000) Cyclooxygenase: structural, cellular and molecular biology. Annual Review of Biochemistry 69: 145-182.
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If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.