Fibrinolysis

Investigators have shown that a decrease in the release of tissue plasminogen activator (tPA) and an elevation of plasminogen activator inhibitor 1 (PAI-1) will reduce fibrinolytic function. It has emerged that triacylglycerol-rich lipoproteins stimulate PAI-1 secretion from endothelial cells, and furthermore it has been shown that OxLDL induces secretion, whereas native LDL has no detectable effect. Lipoprotein (a) (Lp(a)) has also been linked with a decrease in fibrinolysis. Lp(a) is an LDL-like particle consisting of the protein apo(a). It is believed that apo(a) competes with plasminogen and plasmin for binding to fibrin, thus interfering with fibrinolysis; LDL and Lp(a) may represent, therefore, an important link between thrombotic and lipid mechanisms in atherogenesis.

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Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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