Fatty Liver

The triacylglycerol (TG) produced by the liver is mainly delivered to other tissues as very low-density

Table 1 Recommended adequate intakes (AI) for choline

Population

Age

AI (mg day 1)

Infants

0-6 months

125

6-12 months

150

Children

1 through 3years

200

4 through 8years

250

9 through 13years

375

Males

14 through 18years

550

19years and older

550

Females

14 through 18years

400

19 years and older

425

Pregnancy

All ages

450

Lactation

All ages

550

From Institute of Medicine, National Academy of Sciences USA (1998) Dietary reference intakes for folate, thiamin, riboflavin, niacin, vitamin B12, panthothenic acid, biotin, and choline, vol. 1. Washington DC: National Academy Press.

From Institute of Medicine, National Academy of Sciences USA (1998) Dietary reference intakes for folate, thiamin, riboflavin, niacin, vitamin B12, panthothenic acid, biotin, and choline, vol. 1. Washington DC: National Academy Press.

lipoprotein (VLDL) of which lecithin is a required component. In choline deficiency, the diminished ability of liver cells to synthesize new lecithin molecules results in the intracellular accumulation of TG. Treating malnourished patients with high-calorie total parenteral nutrition (TPN) solutions that contain little or no choline will deplete choline stores and cause fatty liver and hepatic dysfunction that can be reversed by treatment with phosphatidylcholine.

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