Fat

Numerous studies have now shown that when humans or animals are allowed to feed ad libitum on high-fat (HF) energy-dense diets, they consume similar amounts (weight) of food but more energy (which is usually accompanied by weight gain) than when they feed ad libitum on lower fat, less energy-dense diets. However, fat is not likely to be the only risk factor for over consumption and few analyses take account of how fat may interact with other nutrients. For instance, sweet high-fat foods have a potent effect on stimulating EI.

We are beginning to gain insights into the effects of types of fat on appetite control, due to the search for forms of fat that do not predispose the general population to weight gain. There is already some evidence that certain subtypes of fat limit the excess EI that occurs as a consequence of ingesting a high-fat diet. In the future specific nutrients could be tailored to exert quantitatively significant effects on appetite control, tissue deposition, and energy balance. In this context it is of note that certain isomers of conjugated linoleic acid (CLA) can be used to suppress appetite and fat deposition in animals and perhaps humans.

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