Evidence for a Role in Alzheimers Disease

Alzheimer's disease (AD) is a progressive, often insidious, dementing disease occurring in mid- to late life. Its incidence increases with age, such that at age 85+ approximately 20% of people suffer from the condition. AD causes neurone death and a reduction in brain volume. The progression of the disease (which in most cases means approximately 7 years of intellectual and personal decline until death) cannot be arrested and eventually patients become bedridden. At this stage, concomitant bedsores, feeding difficulties, and pneumonia result in death.

The diagnosis of AD in made on the basis of the histological examination of brain tissues. These show the presence of widespread accumulations of ^-amyloid senile plaques and neurofibrillary tangles throughout the limbic system and in parts of the cerebral isocortex and brain stem. ^-Amyloid plaque formation occurs in the majority of nondemented elderly individuals, but neurofibrillary tangles are rare. Consequently, it has been suggested that in AD plaque formation precedes and may predispose to neurofibrillary tangle formation.

The etiology of the disease is complex and incompletely understood. Two risk factors for the disease have been identified and confirmed: old age and family history. 'Familial' AD is genetically variable but mutations in chromosome 21 are often involved.

These cases show a marked tendency toward early onset and can be positively identified to represent only a small proportion of the total AD population.

The etiology of nonfamilial, sporadic AD is unknown. However, cases have been attributed to head injury and environmental factors, including aluminum. Involvement of aluminum in AD has been suggested because (1) of the similar symp-tomologies of AD and dialysis dementia; (2) the administration of aluminum to animals produces histological changes within the brain that are, in some respects, similar to those seen in the brains of AD patients; (3) of some reports indicating the presence of aluminum within the cores of senile plaques; (4) of the results of some epidemiological studies that have linked AD incidence either with aluminum levels in drinking water or with its consumption as medicines; and (5) a disease similar to AD is prevalent in some Pacific islands (Guam), where the levels of aluminum in soils and water are high.

However, (1) the pathologies of AD and dialysis dementia are different; (2) the histomorphological changes seen in experimental animals differ, in important respects, from those seen in the brains of AD patients; (3) not all studies have indicated the presence of aluminum within the cores of senile plaques, and attempts to demonstrate enhanced levels of aluminum in the brain of AD patients have mostly failed; (4) the results of the epidemio-logical studies are conflicting and have been criticised on methodological and logical grounds; and (5) Guam disease and AD are clinically different.

It follows that it is now generally accepted that in the absence of a clear association between exposure to aluminum and the disease and/or an identified mechanism for disease induction by the metal, there is insufficient evidence to suggest that aluminum is causative with respect to AD.

See also: Aging. Bone. Food Safety: Heavy Metals.

All About Alzheimers

All About Alzheimers

The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.

Get My Free Ebook


Post a comment