Eosinophilic gastroenteritis affects any part of the bowel from the mouth to the anus, although the stomach and small bowel are the most affected areas. Different layers of the bowel can be affected. It is characterized by eosinophilic infiltration of the affected areas of the bowel and a peripheral blood eosinophilia. It is a rare disorder for which the etiology is unknown.
In patients with mucosal layer disease (i.e., no involvement of muscle or serosal layer), food intolerance should be looked for. A trial of sequential elimination of milk, pork, beef, eggs, or gluten may be tried. Enteral elemental diets have been tried in some patients with success. Patients with mucosal layer disease who do not respond to dietary measures or patients with deeper layer involvement should try a course of steroids. Any patient who has traveled to the tropics should be considered for antihelminth therapy.
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