Diets rich in coconut fat have been reported to raise TxB2 and lower 6-keto-PGF1a concentrations in collagen-activated plasma compared with diets rich in palm or olive oils, indicating a less favourable eicosanoid profile. The main saturated fatty acids of coconut fat — lauric and myristic acids — did not, however, change collagen-induced aggregation in whole-blood samples compared with a diet rich in oleic acid. Also, diets rich in MCFA or palmitic acid did not change collagen-induced aggregation in whole-blood samples. Compared with a diet rich in a mixture of saturated fatty acids, a stearic acid diet increased collagen-induced aggregation in platelet-rich plasma. In addition, a decreased proportion of arachidonic acid in platelet phospholipids was demonstrated after a cocoa butter diet compared with a diet rich in butterfat. Changes in eicosanoid metabolite concentrations in urine, however, were not observed after either diet. These results are conflicting and it is debatable whether measurement in vitro of platelet aggregation truly reflects the situation in vivo.
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