Effects of Diet on LDL Metabolism

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The effects of dietary fat and cholesterol on LDL metabolism have been extensively studied. However, the effects of dietary cholesterol are still highly controversial. Whereas some studies have demonstrated increased LDL production and decreased catabolism associated with high cholesterol intakes, others have failed to find such associations.

Replacement of saturated by polyunsaturated fats has been associated with decreased LDL apo B production in some studies, whereas in other studies, increased ratios of polyunsaturated to saturated fats resulted in increased LDL apo B catabolism. Unlike the effects described for VLDL metabolism, intake of n-3 fatty acids appears to play a minor role on LDL metabolism.

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