Drug Metabolism

The metabolism of drugs and pharmacological agents is not the purview of any single organ system. Older persons tend to be prescribed increasing numbers of medications with advancing age. Important changes in drug metabolism occur with aging. Metabolism and disposition of drugs changes with age. This involves age-associated decrease in function of some, but not all, cytochrome P450 enzymes. Among the pharmacokinetic and pharmacodynamic changes that occur with advancing age are reductions in renal and hepatic clearance and an increased effective half-life of lipid-soluble drugs. The older population shows increased sensitivity to some psy-chotropic drugs and anticoagulants, with the frail elderly being more susceptible than healthy elders.

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