K C McCowen, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA R J Smith, Brown Medical School, Providence, RI, USA
© 2005 Elsevier Ltd. All rights reserved.
Diabetes mellitus is a common, serious metabolic disorder with diverse causes and multiple complications. In this article, the definition and classification are discussed and diagnostic criteria outlined. Subsequently, an overview of the physiology of normal blood glucose homeostasis and normal insulin action leads to consideration of the pathophysiologic events that occur in uncontrolled diabetes.
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